This collection includes minutes and rough minutes of the Managers; Attending Managers' accounts; treasurer's and other financial records; cash books, ledgers, monthly accounts, and receipt books of the steward and matron; materials relating to the medical staff and instruction; patients' records and accounts. There are materials on buildings and grounds and on the library, museum, and the painting of "Christ Healing the Sick" by Benjamin West.

This item contains entries about prominent people (primarily accounts of their deaths); Philadelphia events and gossip; the Pennsylvania Hospital; questions for Meriwether Lewis on Indian physical history, medicine, morals, and religion; and his views on marriage, religion, physicians, etc. Also includes meeting with Captain Wells and Little Turtle; speculations on Indian skin color at the equator.